The Stink in Farts Controls Blood Pressure
A smelly rotten-egg gas in farts controls blood pressure in mice, a new study finds.
I wonder how the scientists determined the smell of mouse farts...
The unpleasant aroma of the gas, called hydrogen sulfide (H2S), can be a little too familiar, as it is expelled by bacteria living in the human colon and eventually makes its way, well, out.
A little too familiar, yup ask any wife ...
The new research found that cells lining mice's blood vessels naturally make the gas and this action can help keep the rodents' blood pressure low by relaxing the blood vessels to prevent hypertension (high blood pressure). This gas is "no doubt" produced in cells lining human blood vessels too, the researchers said.
No doubt just as relaxing to pass it as well... This sounds like one of those "win, win" situations
"Now that we know hydrogen sulfide's role in regulating blood pressure, it may be possible to design drug therapies that enhance its formation as an alternative to the current methods of treatment for hypertension," said Johns Hopkins neuroscientist Solomon H. Snyder, M.D., a co-author of the study detailed in the Oct. 24th issue of the journal Science.
More beans...
Snyder and his colleagues compared normal mice to mice that were missing a gene for an enzyme known as CSE, long suspected as being responsible for making hydrogen sulfide. As they measured hydrogen sulfide levels taken from tissues of the CSE-deficient mice, the scientists found that the gas was depleted in the cardiovascular systems of the altered mice. By contrast, normal mice had higher levels of the gas, thereby showing that hydrogen sulfide is naturally made by mammalian tissues using CSE.
So I guess thousands of men will now be telling their wives that far from being disgusting they are normal and healthy...
Next, the mice were subjected to higher blood pressures comparable to serious hypertension in humans. Scientists had them respond to a chemical called methacholine that relaxes normal blood vessels. The blood vessels of the CSE-lacking mice hardly relaxed, indicating that hydrogen sulfide is a huge contender for regulating blood pressure. So since I have high blood pressure and suffer no lack of hydogen sulfide, I guess that means...more beans! My poor wife and children. Please pray for them...
Hydrogen sulfide is the most recently discovered member of a family of gasotransmitters, small molecules inside our bodies with important physiological functions. Gasotransmitters...heh
This study is the first to reveal that the CSE enzyme that triggers hydrogen sulfide is activated itself in the same way as other enzymes when they trigger their respective gasotransmitter, such as a nitric oxide-forming enzyme that also regulates blood pressure, Dr. Snyder said.
Because gasotransmitters are common in mammals all over the evolutionary tree, these findings on the importance of hydrogen sulfide are thought to have broad applications to human diseases, such as diabetes and neurodegenerative diseases.
Maybe it's more related to politics than I thought..
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